Mice derived from <i>in vitro</i> αMEM-cultured preimplantation embryos exhibit postprandial hyperglycemia and higher inflammatory gene expression in peripheral leukocytes

ABSTRACT We examined whether peripheral leukocytes of mice derived from in vitro αMEM-cultured embryos and exhibiting type 2 diabetes had higher expression inflammatory-related genes associated with the development atherosclerosis. Also, we impact a barley diet on inflammatory gene expression. Adult were produced by embryo transfer, after culturing two-cell for 48 h either α minimal essential media (α-MEM) or potassium simplex optimized medium control media. Mice fed rice 10 weeks. Postprandial blood glucose mRNA levels several genes, including Tnfa Nox2, significantly MEM compared mice. Barley intake reduced S100a8 Nox2. In summary, exhibited postprandial hyperglycemia related to atherosclerosis, some